Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease.

ABSTRACT: Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Exercise intolerance may result from reduced skeletal muscle capillary density and impaired muscle oxygen delivery. This cross-sectional study tested the hypothesis that capillary density is related to claudication times and anaerobic threshold (AT) in patients with PAD. A total of 37 patients with PAD and 29 control subjects performed cardiopulmonary exercise testing on a treadmill for AT and gastrocnemius muscle biopsies. Skeletal muscle capillary density was measured using immunofluorescence staining. PAD had decreased capillary density (278 ± 87 vs 331 ± 86 endothelial cells/mm², p = 0.05), peak VO₂ (15.7 ± 3.9 vs

SUBMITTER: Duscha BD 

PROVIDER: S-EPMC8297535 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature