Translational PET applications for brain circuit mapping with transgenic neuromodulation tools.

ABSTRACT: Transgenic neuromodulation tools have transformed the field of neuroscience over the past two decades by enabling targeted manipulation of neuronal populations and circuits with unprecedented specificity. Chemogenetic and optogenetic neuromodulation systems are among the most widely used and allow targeted control of neuronal activity through the administration of a selective compound or light, respectively. Innovative genetic targeting strategies are utilized to transduce specific cells to express transgenic receptors and opsins capable of manipulating neuronal activity. These allow mapping of neuroanatomical projection sites and link cellular manipulations with brain circuit functions and behavior. As these tools continue to expand knowledge of the nervous system in preclinical models, d

SUBMITTER: Boehm MA 

PROVIDER: S-EPMC8297666 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature