Clinical evaluation of allogeneic eye drops from cord blood platelet lysate.

ABSTRACT:

Background

Current treatments for several corneal lesions show limited efficacy. Here we report the clinical evaluation of the efficacy of a novel eye drop preparation produced in a public cord blood (CB) bank.

Materials and methods

In a multicentre, retrospective, consecutive case study we evaluated 33 patients (46 eyes) unresponsive to conventional treatments who required urgent intervention. The patients were given allogeneic eye drops obtained from cord blood platelet lysate (CBED) to treat severe ocular surface lesions under a compassionate use protocol. The CBED were prepared from CB units donated for haematopoietic stem cell transplantation that did not contain the minimum stem cell dose required for this use. Patients were grouped by acute conditions (neurotrophic ul

SUBMITTER: Samarkanova D 

PROVIDER: S-EPMC8297669 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature