Forgiveness of Dolutegravir-Based Triple Therapy Compared With Older Antiretroviral Regimens: A Prospective Multicenter Cohort of Adherence Patterns and HIV-RNA Replication.

ABSTRACT:

Background

For many people with HIV (PWH), taking antiretroviral therapy (ARV) every day is difficult.

Methods

Average adherence (Av-Adh) and log-transformed treatment interruption (TI) to ARV were prospectively measured over 6 months using electronic drug monitoring (EDM) in several cohorts of PWH. Multivariate linear regression models including baseline confounders explored the influence of EDM-defined adherence (R ²) on 6-month log₁₀ HIV-RNA. Multivariate logistic regression models were used to compare the risk of HIV-RNA detection (VR) within subgroups stratified by lower (≤95%) and higher (>95%) Av-Adh.

Results

Three hundred ninety-nine PWH were analyzed with different ARVs: dolutegravir (n = 102), raltegravir (n = 90), boosted PI (bP

SUBMITTER: Parienti JJ 

PROVIDER: S-EPMC8297697 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature