A tightly clustered hepatitis E virus genotype 1a is associated with endemic and outbreak infections in Bangladesh.

ABSTRACT:

Background

Hepatitis E virus (HEV) infection is endemic in Bangladesh and there are occasional outbreaks. The molecular characteristics and pathogenesis of endemic and outbreak HEV strains are poorly understood. We compared the genetic relatedness and virulence associated mutations of endemic HEV strains with outbreak strains.

Methods

We analyzed systematically collected serum samples from HEV immunoglobulin M (IgM) positive patients attended at Bangabandhu Sheikh Mujib Medical University, Dhaka from August 2013 to June 2015. HEV RNA positive samples were subjected to whole genome sequencing. Genotype and subtype of the strains were determined by phylogenetic analysis. Virulence associated mutations e.g. acute viral hepatitis (AVH), fulminant hepatic failure (FHF), chronic h

SUBMITTER: Hoa TN 

PROVIDER: S-EPMC8297744 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature