Both high and low pre-infection glucose levels associated with increased risk for severe COVID-19: New insights from a population-based study.

ABSTRACT:

Importance

Patients with diabetes are known to be at increased risk for infections including severe coronavirus disease 2019 (COVID-19) but the relationship between COVID-19 severity and specific pre-infection glucose levels is not known.

Objective

To assess the differential effects of pre-infection glucose levels on the risk for severe COVID-19 amongst patients with and without diabetes.

Design

Population based historical cohort study.

Setting

National state-mandated HMO.

Patients

All adult patients with a positive SARS-COV2 test between March-October 2020.

Exposure

Recent fasting blood glucose (FBG) and glycated hemoglobin (HBA1C), age, gender, body mass index (BMI) and diagnoses of diabetes, hypertension, ischemic heart disease.

Outcome

SUBMITTER: Shauly-Aharonov M 

PROVIDER: S-EPMC8297851 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature