Different Approaches to Analyze Muscle Fat Replacement With Dixon MRI in Pompe Disease.

ABSTRACT: Quantitative MRI is an increasingly used method to monitor disease progression in muscular disorders due to its ability to measure changes in muscle fat content (reported as fat fraction) over a short period. Being able to objectively measure such changes is crucial for the development of new treatments in clinical trials. However, the analysis of the images involved continues to be a daunting task because of the time needed. Whether a more specific analysis selecting individual muscles or a global one analyzing the whole thigh or compartments could be a suitable alternative has only been marginally studied. In our study we compare three methods of analysis of 2-point-dixon images in a cohort of 34 patients with late onset Pompe disease followed over a period of one year. We measured fat f

SUBMITTER: Alonso-Jimenez A 

PROVIDER: S-EPMC8298190 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature