Recurrent urinary tract infection: Association of clinical profiles with urobiome composition in women.

ABSTRACT:

Aims

Clinical profiles of women with recurrent urinary tract infection (RUTI) are correlated with their urinary microbes.

Methods

This IRB-approved, cross-sectional study enrolled adult women with RUTI. Urine samples (catheterized and voided) underwent culture by expanded quantitative urine culture (EQUC) and standard urine culture (SUC) methods. A validated symptom questionnaire, relevant clinical variables, and EQUC were used to identify symptom clusters and detect associations with specific urinary microbes.

Results

Most (36/43) participants were postmenopausal; the average age was 67 years. 51% reported vaginal estrogen use; 51% reported sexual activity. Although single symptoms were not associated with specific urinary microbes, EQUC results were correlated with

SUBMITTER: Burnett LA 

PROVIDER: S-EPMC8298270 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature