Splanchnic nerve modulation in heart failure: mechanistic overview, initial clinical experience, and safety considerations.

ABSTRACT: Volume recruitment from the splanchnic compartment is an important physiological response to stressors such as physical activity and blood loss. In the setting of heart failure (HF), excess fluid redistribution from this compartment leads to increased cardiac filling pressures with limitation in exercise capacity. Recent evidence suggests that blocking neural activity of the greater splanchnic nerve (GSN) could have significant benefits in some patients with HF by reducing cardiac filling pressures and improving exercise capacity. However, to date the long-term safety of splanchnic nerve modulation (SNM) in the setting of HF is unknown. SNM is currently used in clinical practice to alleviate some forms of chronic abdominal pain. A systematic review of the series where permanent SNM was use

SUBMITTER: Fudim M 

PROVIDER: S-EPMC8298285 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature