A prefrontal network integrates preferences for advance information about uncertain rewards and punishments.

ABSTRACT: Humans and animals can be strongly motivated to seek information to resolve uncertainty about rewards and punishments. In particular, despite its clinical and societal relevance, very little is known about information seeking about punishments. We show that attitudes toward information about punishments and rewards are distinct and separable at both behavioral and neuronal levels. We demonstrate the existence of prefrontal neuronal populations that anticipate opportunities to gain information in a relatively valence-specific manner, separately anticipating information about either punishments or rewards. These neurons are located in anatomically interconnected subregions of anterior cingulate cortex (ACC) and ventrolateral prefrontal cortex (vlPFC) in area 12o/47. Unlike ACC, vlPFC also co

SUBMITTER: Jezzini A 

PROVIDER: S-EPMC8298287 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature