In vivo parameter identification in arteries considering multiple levels of smooth muscle activity.

ABSTRACT: In this paper an existing in vivo parameter identification method for arteries is extended to account for smooth muscle activity. Within this method a continuum-mechanical model, whose parameters relate to the mechanical properties of the artery, is fit to clinical data by solving a minimization problem. Including smooth muscle activity in the model increases the number of parameters. This may lead to overparameterization, implying that several parameter combinations solve the minimization problem equally well and it is therefore not possible to determine which set of parameters represents the mechanical properties of the artery best. To prevent overparameterization the model is fit to clinical data measured at different levels of smooth muscle activity. Three conditions are considered for

SUBMITTER: Gade JL 

PROVIDER: S-EPMC8298368 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature