Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons.

ABSTRACT: Kinases play critical roles in synaptic and neuronal changes involved in the formation of memory. However, significant gaps exist in the understanding of how interactions among kinase pathways contribute to the mechanistically distinct temporal domains of memory ranging from short-term memory to long-term memory (LTM). Activation of protein kinase A (PKA) and mitogen-activated protein kinase (MAPK)-ribosomal S6 kinase (RSK) pathways are critical for long-term enhancement of neuronal excitability (LTEE) and long-term synaptic facilitation (LTF), essential processes in memory formation. This study provides new insights into how these pathways contribute to the temporal domains of memory, using empirical and computational approaches. Empirical studies of Aplysia sensory neurons identified a p

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8298407 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature