Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.

ABSTRACT: Family and population studies indicate clear heritability of major depressive disorder (MDD), though its underlying biology remains unclear. The majority of single-nucleotide polymorphism (SNP) linkage blocks associated with MDD by genome-wide association studies (GWASes) are believed to alter transcriptional regulators (e.g., enhancers, promoters) based on enrichment of marks correlated with these functions. A key to understanding MDD pathophysiology will be elucidation of which SNPs are functional and how such functional variants biologically converge to elicit the disease. Furthermore, retinoids can elicit MDD in patients and promote depressive-like behaviors in rodent models, acting via a regulatory system of retinoid receptor transcription factors (TFs). We therefore sought to simulta

SUBMITTER: Mulvey B 

PROVIDER: S-EPMC8298436 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature