Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages.

ABSTRACT: Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2 expression is controlled by the Tie2 promoter. Tie2^CRE/+;Bmp2^tg/tg mice develop aortic valve dysfunction postnatally, accompanied by pre-calcific lesion formation in valve leaflets. Remarkably, Tie2^CRE/+;Bmp2^tg/tg mice develop extensive soft tissue bone formation typical of acquired forms of heterotopic ossification (HO) and genetic bone disorders, such as Fibrodysplasia Ossificans Progressiva (FOP). Ectopic ossification in Tie2^CRE/+;Bmp2^tg/tg transgenic animals is accompanied by increased bone marrow

SUBMITTER: Prados B 

PROVIDER: S-EPMC8298441 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature