PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue.

ABSTRACT: This study evaluated the MRI-derived fat fraction (FF), from a Cooling-reheating protocol, for estimating the cold-induced brown adipose tissue (BAT) metabolic rate of glucose (MR_glu) and changes in lipid content, perfusion and arterial blood volume (V_A) within cervical-supraclavicular fat (sBAT). Twelve volunteers underwent PET/MRI at baseline, during cold exposure and reheating. For each temperature condition, perfusion and V_A were quantified with dynamic [¹⁵O]water-PET, and FF, with water-fat MRI. MR_glu was assessed with dynamic [¹⁸F]fluorodeoxyglucose-PET during cold exposure. sBAT was defined using anatomical criteria, and its subregion sBAT_HI, by MR_glu > 11 μmol/100 cm³/min. For all tem

SUBMITTER: Lundstrom E 

PROVIDER: S-EPMC8298487 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature