Structure and function of an Arabidopsis thaliana sulfate transporter.

ABSTRACT: Plant sulfate transporters (SULTR) mediate absorption and distribution of sulfate (SO₄^2-) and are essential for plant growth; however, our understanding of their structures and functions remains inadequate. Here we present the structure of a SULTR from Arabidopsis thaliana, AtSULTR4;1, in complex with SO₄^2- at an overall resolution of 2.8 Å. AtSULTR4;1 forms a homodimer and has a structural fold typical of the SLC26 family of anion transporters. The bound SO₄^2- is coordinated by side-chain hydroxyls and backbone amides, and further stabilized electrostatically by the conserved Arg393 and two helix dipoles. Proton and SO₄^2- are co-transported by AtSULTR4;1 and a proton gradient significantly enhances SO<

SUBMITTER: Wang L 

PROVIDER: S-EPMC8298490 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature