Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study.

ABSTRACT: It is well-known that hypertension exacerbates chronic kidney disease (CKD) progression, however, the optimal target blood pressure (BP) level in patients with CKD remains unclear. This study aimed to assess the optimal BP level for preventing CKD progression. The risk of renal outcome among different BP categories at baseline as well as 1 year after, were evaluated using individual CKD patient data aged between 40 and 74 years from FROM-J [Frontier of Renal Outcome Modifications in Japan] study. The renal outcome was defined as ≥ 40% reduction in estimated glomerular filtration rate to < 60 mL/min/1.73 m², or a diagnosis of end stage renal disease. Regarding baseline BP, the group of systolic BP (SBP) 120-129 mmHg had the lowest risk of the renal outcome, which increased more t

SUBMITTER: Tsuchida-Nishiwaki M 

PROVIDER: S-EPMC8298520 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature