Periodontitis induces endothelial dysfunction in mice.

ABSTRACT: The treatment of periodontitis has numerous positive effects on established chronic health conditions, including cardiovascular disease and diabetes. However, ethical considerations do limit the establishment of human trials to investigate whether periodontitis promotes the early stages of chronic conditions. Therefore, the aim of this study was to investigate whether periodontitis induces endothelial dysfunction in hyperlipidemic apolipoprotein E gene-deficient (ApoE^-/-) mice. Forty-five 8-week-old ApoE^-/- mice were challenged by oral lavage with Porphyromonas gingivalis and Streptococcus gordonii for 4 weeks. A subgroup of animals (n = 15-17/group) was placed in a metabolic chamber immediately before euthanasia at 4 weeks to measure VO₂/CO₂ con

SUBMITTER: Parvaneh M 

PROVIDER: S-EPMC8298548 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature