No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing.

ABSTRACT: The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation forthe variance in this heterogeneous condition. Peripheral blood measures of cytokines and chemokines constitute the bulk of evidence, with consistent meta-analytic data implicating raised proinflammatory cytokines such as IL6, IL1β and TNF. Among the potential mechanisms linking immunobiological changes to affective neurobiology is the accelerated biological ageing seen in MDD, particularly via the senescence associated secretory phenotype (SASP). However, the cellular source of immunobiological markers remains unclear. Pre-clinical evidence suggests a role for peripheral blood mononuclear cells (PBMC), thus here we aimed to explore

SUBMITTER: Cole JJ 

PROVIDER: S-EPMC8298604 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature