Tremorography in fragile X-associated tremor/ataxia syndrome, Parkinson's disease and essential tremor.

ABSTRACT:

Background

Fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disease affecting carriers of a 55-200 CGG repeat in the fragile X mental retardation 1 gene, may receive an initial diagnosis of Parkinson's disease (PD) or essential tremor (ET) due to overlapping motor symptoms. Therefore, tremor and bradykinesia were compared in these disorders using quantitative tremorography.

Methods

The inertial sensor based Kinesia ™ system was used to quantify upper extremity tremor and bradykinesia in participants with FXTAS (n = 25), PD (n = 23), ET (n = 18) and controls (n = 20) and regression analysis was performed to determine whether tremorography measures distinguished between the groups. The FXTAS Rating scale (FXTAS-

SUBMITTER: Robertson EE 

PROVIDER: S-EPMC8298795 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature