Mnemonic Similarity Task to study episodic memory in Parkinson's disease.

ABSTRACT:

Introduction

Parkinson's disease (PD) patients commonly experience episodic memory impairments, which are associated with an increased risk of dementia. The Mnemonic Similarity Task (MST) is a well-validated test to investigate episodic memory changes in healthy aging and in neurodegenerative diseases but has not been studied in PD patients.

Methods

In the MST task, participants respond during a testing phase whether visualized images are "repeat", "similar", or "new", compared to images previously shown during an encoding phase. We tested 17 PD without cognitive impairment (level-II criteria), both off (PD-OFF) and on (PD-ON) dopaminergic medications; and compared PD-OFF with 17 age- and education-matched healthy controls (HC).

Results

We found no influence of dopami

SUBMITTER: Das T 

PROVIDER: S-EPMC8298797 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature