Myocardial Vasculitis Associated With the Immune Checkpoint Inhibitor Pembrolizumab.
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ABSTRACT:
SUBMITTER: Oishi H
PROVIDER: S-EPMC8299122 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Myocardial Vasculitis Associated With the Immune Checkpoint Inhibitor Pembrolizumab.
Oishi Hideo H Morimoto Ryota R Shimoyama Yoshie Y Kuroda Kei K Urata Toru T Kondo Toru T Okumura Takahiro T Bando Yasuko K YK Akiyama Masashi M Murohara Toyoaki T
JACC. Case reports 20200923 12
Recent developments in immune checkpoint inhibitors (ICIs) have provided new treatment strategies for advanced cancer. However, ICIs lead to an imbalance between T cell-mediated inflammatory responses and immune tolerance in the myocardium. Here we report the first case that implicates the contribution of ICI-induced vasculitis to myocardial injury. (<b>Level of Difficulty: Intermediate.</b>). ...[more]
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