Humoral immunity to SARS-CoV-2 and seasonal coronaviruses in children and adults in north-eastern France.

ABSTRACT:

Background

Children are underrepresented in the COVID-19 pandemic and often experience milder disease than adolescents and adults. Reduced severity is possibly due to recent and more frequent seasonal human coronaviruses (HCoV) infections. We assessed the seroprevalence of SARS-CoV-2 and seasonal HCoV specific antibodies in a large cohort in north-eastern France.

Methods

In this cross-sectional seroprevalence study, serum samples were collected from children and adults requiring hospital admission for non-COVID-19 between February and August 2020. Antibody responses to SARS-CoV-2 and seasonal HCoV (229E, HKU1, NL63, OC43) were assessed using a bead-based multiplex assay, Luciferase-Linked ImmunoSorbent Assay, and a pseudotype neutralisation assay.

Findings

In 2,408 in

SUBMITTER: Woudenberg T 

PROVIDER: S-EPMC8299153 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature