Tissue-specific activation of Myd88-dependent pathways governs disease severity in primary Sjogren's syndrome.

ABSTRACT: Myd88 activation is an important driver of autoimmunity. Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by exocrine gland dysfunction in combination with serious systemic disease manifestations. Myd88-dependent signaling networks remain incompletely understood in the context of pSS. The objective of this study was to establish the contribution of tissue-specific Myd88 activation to local (exocrine) and systemic pSS manifestations. To this end, we generated two novel conditional knockout pSS mouse models; one lacking Myd88 in hematopoietic cells and a second strain in which Myd88 was deleted in the stromal compartment. Spontaneous production of inflammatory mediators was altered in salivary tissue, and nephritis was diminished in both conditional knockout strains. I

SUBMITTER: Kiripolsky J 

PROVIDER: S-EPMC8299268 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature