Circulating miR-206 and Wnt-signaling are associated with cardiovascular complications and a history of preeclampsia in women.

ABSTRACT: Women with a history of preeclampsia (PE) have increased risk of cardiovascular disease (CVD) later in life. However, the molecular determinants underlying this risk remain unclear. We sought to understand how circulating miRNA levels are affected by prior PE, and related to biological pathways underpinning cardiovascular disease. RNA sequencing was used to profile plasma levels of 2578 miRNAs in a retrospective study of women with a history of PE or normotensive pregnancy, in two independent cohorts with either acute coronary syndrome (ACS) (n = 17-18/group) or no ACS (n = 20/group). Differential miRNA alterations were assessed in relation to a history of PE (within each cohort) or ACS (across cohorts), and compared with miRNAs previously reported to be altered during PE. A history of PE

SUBMITTER: Schlosser K 

PROVIDER: S-EPMC8299351 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature