Continual Decline in Azole Susceptibility Rates in Candida tropicalis Over a 9-Year Period in China.

ABSTRACT:

Background

There have been reports of increasing azole resistance in Candida tropicalis, especially in the Asia-Pacific region. Here we report on the epidemiology and antifungal susceptibility of C. tropicalis causing invasive candidiasis in China, from a 9-year surveillance study.

Methods

From August 2009 to July 2018, C. tropicalis isolates (n = 3702) were collected from 87 hospitals across China. Species identification was carried out by mass spectrometry or rDNA sequencing. Antifungal susceptibility was determined by Clinical and Laboratory Standards Institute disk diffusion (CHIF-NET10-14, n = 1510) or Sensititre YeastOne (CHIF-NET15-18, n = 2192) methods.

Results

Overall, 22.2% (823/3702) of the isolates were resistant t

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8299486 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature