A chemokine/chemokine receptor signature potentially predicts clinical outcome in colorectal cancer patients.

ABSTRACT:

Background

Differential expression of chemokines/chemokine receptors in colorectal cancer (CRC) may enable molecular characterization of patients' tumors for predicting clinical outcome.

Objective

To evaluate the prognostic ability of these molecules in a CRC cohort and the CRC TCGA-dataset.

Methods

Chemokine (CXCL-12α, CXCL-12β, IL-17A, CXCL-8, GM-CSF) and chemokine receptor (CXCR-4, CXCR-7) transcripts were analyzed by RT-qPCR in 76 CRC specimens (normal: 27, tumor: 49; clinical cohort). RNA-Seq data was analyzed from the TCGA-dataset (n= 375). Transcript levels were correlated with outcome; analyses: univariate, multivariable, Kaplan-Meier.

Results

In the clinical cohort, chemokine/chemokine receptor levels were elevated 3-10-fold in CRC specimens (P⩽ 0.004)

SUBMITTER: Mitchell A 

PROVIDER: S-EPMC8299666 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature