Identification of Microbiota Biomarkers With Orthologous Gene Annotation for Type 2 Diabetes.

ABSTRACT: Type 2 diabetes (T2D) is a systematic chronic metabolic condition with abnormal sugar metabolism dysfunction, and its complications are the most harmful to human beings and may be life-threatening after long-term durations. Considering the high incidence and severity at late stage, researchers have been focusing on the identification of specific biomarkers and potential drug targets for T2D at the genomic, epigenomic, and transcriptomic levels. Microbes participate in the pathogenesis of multiple metabolic diseases including diabetes. However, the related studies are still non-systematic and lack the functional exploration on identified microbes. To fill this gap between gut microbiome and diabetes study, we first introduced eggNOG database and KEGG ORTHOLOGY (KO) database for orthologous

SUBMITTER: Zhang YH 

PROVIDER: S-EPMC8299781 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature