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GPA-Induced Granulomatous Endocarditis Mimicking a Thrombotic Mitral Valve Stenosis.

ABSTRACT: We present the case of a patient with granulomatous endocarditis of the mitral valve leading to severe valve stenosis caused by granulomatosis with polyangiitis. Endocarditis is a rare complication of granulomatosis with polyangiitis that may be misdiagnosed as infectious endocarditis or, as in our case, thrombotic lesions. (Level of Difficulty: Intermediate.).

SUBMITTER: Marquetand C

PROVIDER: S-EPMC8299858 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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GPA-Induced Granulomatous Endocarditis Mimicking a Thrombotic Mitral Valve Stenosis.

Marquetand Christoph C Lamprecht Peter P Dressler Franz F FF Perner Sven S Holl-Ulrich Konstanze K Stierle Ulrich U Aboud Anas A Reil Jan-Christian JC

JACC. Case reports 20201014 14

We present the case of a patient with granulomatous endocarditis of the mitral valve leading to severe valve stenosis caused by granulomatosis with polyangiitis. Endocarditis is a rare complication of granulomatosis with polyangiitis that may be misdiagnosed as infectious endocarditis or, as in our case, thrombotic lesions. (<b>Level of Difficulty: Intermediate.</b>). ...[more]

PMID: 34317127

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Rapidly progressive mitral valve disease from non-bacterial thrombotic endocarditis to mitral stenosis in systemic lupus erythematosus: a case report.

Project description:BackgroundLibman-Sacks endocarditis), a non-bacterial thrombotic endocarditis (NBTE) linked to systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS), typically causes valve regurgitation and embolism but can rarely mimic rheumatic mitral stenosis (MS).Case summaryThis case involves a 59-year-old woman with a history of APS and SLE who presented with worsening dyspnoea and congestive heart failure. Initially, severe mitral regurgitation (MR) due to NBTE resolved with vitamin K antagonist therapy, yet she subsequently developed significant MS with commissural fusion, a rheumatic-like feature. Despite stable SLE activity, echocardiography revealed severe MS with high pulmonary pressures, warranting surgical valve replacement. Intraoperative findings confirmed rheumatic-like degeneration, but the patient experienced a fatal cerebral infarction post-surgery, likely due to APS.DiscussionThis case highlights the progression of NBTE-related MR to rheumatic-like MS in an SLE patient with APS, an unusual clinical course. It underscores the importance of echocardiographic monitoring in similar cases, as chronic inflammatory changes in APS might mimic rheumatic pathology, necessitating vigilant management and timely intervention.

| S-EPMC11886785 | biostudies-literature

Extensive Vegetation on the Mitral Valve Due to Non-Bacterial Thrombotic Endocarditis.