The Drosophila E78 nuclear receptor regulates dietary triglyceride uptake and systemic lipid levels.

ABSTRACT:

Background

Lipid levels are maintained by balancing lipid uptake, synthesis, and mobilization. Although many studies have focused on the control of lipid synthesis and mobilization, less is known about the regulation of lipid digestion and uptake.

Results

Here we show that the Drosophila E78A nuclear receptor plays a central role in intestinal lipid homeostasis through regulation of the CG17192 digestive lipase. E78A mutant adults fail to maintain proper systemic lipid levels following eclosion, with this effect largely restricted to the intestine. Transcriptional profiling by RNA-seq revealed a candidate gene for mediating this effect, encoding the predicted adult intestinal lipase CG17192. Intestine-specific disruption of CG17192 results in reduced lipid levels similar to

SUBMITTER: Praggastis SA 

PROVIDER: S-EPMC8299869 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature