Solvent exposed occupations and risk of Parkinson disease in Finland.

ABSTRACT:

Introduction

Epidemiologic and toxicology studies suggest that exposure to various solvents, especially chlorinated hydrocarbon solvents, might increase Parkinson disease (PD) risk.

Methods

In a population-based case-control study in Finland, we examined whether occupations with potential for solvent exposures were associated with PD. We identified newly diagnosed cases age 45-84 from a nationwide medication reimbursement register in 1995-2014. From the population register, we randomly selected non-PD controls matched on sex, along with birth and diagnosis years (age). We included 11,757 cases and 23,236 controls with an occupation in the 1990 census, corresponding to age 40-60. We focused on 28 occupations with ≥ 5% probability of solvent exposure according to the Finnish J

SUBMITTER: Nielsen SS 

PROVIDER: S-EPMC8299961 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature