Pathophysiological mechanisms of bradycardia in patients with anorexia nervosa.

ABSTRACT:

Background

The purpose of this investigation was to examine heart rate variability (HRV), interbeat interval (IBI), and their interrelationship in healthy controls, bradycardic hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) mutation carriers, and patients with anorexia nervosa (AN). We tested the hypothesis that neural mechanisms cause bradycardia in patients with AN. Therefore, we assumed that saturation of the HRV/IBI relationship as a consequence of sustained parasympathetic control of the sinus node is exclusively detectable in patients with AN.

Methods

Patients with AN between the ages of 12 and 16 years admitted to our hospital due to malnutrition were grouped and included in the present investigation (N = 20). A matched-pair group with hea

SUBMITTER: Buchhorn R 

PROVIDER: S-EPMC8299991 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature