Conservation of Imprinting and Methylation of MKRN3, MAGEL2 and NDN Genes in Cattle.

ABSTRACT: Genomic imprinting is the epigenetic mechanism of transcriptional regulation that involves differential DNA methylation modification. Comparative analysis of imprinted genes between species can help us to investigate the biological significance and regulatory mechanisms of genomic imprinting. MKRN3, MAGEL2 and NDN are three maternally imprinted genes identified in the human PWS/AS imprinted locus. This study aimed to assess the allelic expression of MKRN3, MAGEL2 and NDN and to examine the differentially methylated regions (DMRs) of bovine PWS/AS imprinted domains. An expressed single-nucleotide polymorphism (SNP)-based approach was used to investigate the allelic expression of MKRN3, MAGEL2 and NDN genes in bovine adult tissue

SUBMITTER: Li J 

PROVIDER: S-EPMC8300276 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature