ILC2s Improve Glucose Metabolism Through the Control of Saturated Fatty Acid Absorption Within Visceral Fat.

ABSTRACT:

Background and aims

Group 2 innate lymphoid cells (ILC2s) have been implicated in the regulation of metabolic homeostasis in mice.

Methods

In this study, the role of ILC2s in white adipose tissue (WAT) was investigated using ST2, an IL-33 receptor that is expressed on ILC2 knockout mice.

Results

The deficiency of ST2 decreased ILC2s in WAT, whereas ex-ILC2, which acquired group 1 innate lymphoid cell (ILC1)-like traits, was increased. This led to significant metabolic disorders such as visceral fat obesity, decreased browning in WAT, reduction of energy metabolism, and impaired glucose tolerance, compared to wild type (WT) mice. Those metabolic abnormalities of ST2-knockout (ST2KO) mice were not ameliorated by IL-33 administration, but impaired glucose tolerance and v

SUBMITTER: Okamura T 

PROVIDER: S-EPMC8300428 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature