Crystal Structure of the [FeFe]-Hydrogenase Maturase HydE Bound to Complex-B.

ABSTRACT: [FeFe]-hydrogenases use a unique organometallic complex, termed the H cluster, to reversibly convert H₂ into protons and low-potential electrons. It can be best described as a [Fe₄S₄] cluster coupled to a unique [2Fe]_H center where the reaction actually takes place. The latter corresponds to two iron atoms, each of which is bound by one CN^- ligand and one CO ligand. The two iron atoms are connected by a unique azadithiolate molecule (^-S-CH₂-NH-CH₂-S^-) and an additional bridging CO. This [2Fe]_H center is built stepwise thanks to the well-orchestrated action of maturating enzymes that belong to the Hyd machinery. Among them, HydG converts l-tyrosine into CO and CN^- to prod

SUBMITTER: Rohac R 

PROVIDER: S-EPMC8300475 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature