Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens.
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ABSTRACT:
SUBMITTER: Scoffone VC
PROVIDER: S-EPMC8300704 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
Role of RND Efflux Pumps in Drug Resistance of Cystic Fibrosis Pathogens.
Scoffone Viola Camilla VC Trespidi Gabriele G Barbieri Giulia G Irudal Samuele S Perrin Elena E Buroni Silvia S
Antibiotics (Basel, Switzerland) 20210715 7
Drug resistance represents a great concern among people with cystic fibrosis (CF), due to the recurrent and prolonged antibiotic therapy they should often undergo. Among Multi Drug Resistance (MDR) determinants, Resistance-Nodulation-cell Division (RND) efflux pumps have been reported as the main contributors, due to their ability to extrude a wide variety of molecules out of the bacterial cell. In this review, we summarize the principal RND efflux pump families described in CF pathogens, focusi ...[more]
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