Hidrox^® and Chronic Cystitis: Biochemical Evaluation of Inflammation, Oxidative Stress, and Pain.

ABSTRACT: Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic bladder condition characterized by frequent urination, inflammation, oxidative stress, and pain. The aim of the study was to evaluate the anti-inflammatory and antioxidant effects of an oral administration of Hidrox^® (10 mg/kg) in the bladder and spinal cord in a rodent model of IC/BPS. The chronic animal model of cystitis was induced by repeated intraperitoneal injections of cyclophosphamide (CYP) for five consecutive days. Treatment with Hidrox^® began on the third day of the CYP injection and continued until the 10th day. CYP administration caused macroscopic and histological bladder changes, inflammatory infiltrates, increased mast cell numbers, oxidative stress, decreased expression of the tight

SUBMITTER: D'Amico R 

PROVIDER: S-EPMC8300770 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature