Genetic Testing for Antipsychotic Pharmacotherapy: Bench to Bedside.

ABSTRACT: There is growing research interest in learning the genetic basis of response and adverse effects with psychotropic medications, including antipsychotic drugs. However, the clinical utility of information from genetic studies is compromised by their controversial results, primarily due to relatively small effect and sample sizes. Clinical, demographic, and environmental differences in patient cohorts further explain the lack of consistent results from these genetic studies. Furthermore, the availability of psychopharmacological expertise in interpreting clinically meaningful results from genetic assays has been a challenge, one that often results in suboptimal use of genetic testing in clinical practice. These limitations explain the difficulties in the translation of psychopharmacological

SUBMITTER: Shad MU 

PROVIDER: S-EPMC8301006 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature