Neuroprotective Effect of 4-Phenylbutyric Acid against Photo-Stress in the Retina.

ABSTRACT: Exposure to excessive visible light causes retinal degeneration and may influence the progression of retinal blinding diseases. However, there are currently no applied treatments. Here, we focused on endoplasmic reticulum (ER) stress, which can cause cellular degeneration and apoptosis in response to stress. We analyzed functional, histological, and molecular changes in the light-exposed retina and the effects of administering an ER-stress inhibitor, 4-phenylbutyric acid (4-PBA), in mice. We found that light-induced visual function impairment related to photoreceptor cell loss and outer segment degeneration were substantially suppressed by 4-PBA administration, following attenuated photoreceptor apoptosis. Induction of retinal ER stress soon after light exposure, represented by upregulatio

SUBMITTER: Guzman Mendoza NA 

PROVIDER: S-EPMC8301054 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature