Prognostic validation and clinical implications of the EANO ESMO classification of leptomeningeal metastasis from solid tumors.

ABSTRACT:

Background

The EANO ESMO guidelines have proposed a classification of leptomeningeal metastases (LM) from solid cancers based on clinical, magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) cytology presentation. MRI patterns are classified as linear, nodular, both, or neither. Type I LM is defined by positive CSF cytology (confirmed LM) whereas type II LM is defined by typical clinical and MRI signs (probable or possible LM). Here we explored the clinical utility of these LM subtypes.

Patients and methods

We retrospectively assembled data from 254 patients with newly diagnosed LM from solid tumors. Survival curves were derived using the Kaplan-Meier method and compared by Log-rank test.

Results

Median age at LM diagnosis was 56 years. Typical clinical LM

SUBMITTER: Le Rhun E 

PROVIDER: S-EPMC8301235 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature