Effective Detection and Monitoring of Glioma Using [¹⁸F]FPIA PET Imaging.

ABSTRACT:

Background

Reprogrammed cellular metabolism is a cancer hallmark. In addition to increased glycolysis, the oxidation of acetate in the citric acid cycle is another common metabolic phenotype. We have recently developed a novel fluorine-18-labelled trimethylacetate-based radiotracer, [¹⁸F]fluoro-pivalic acid ([¹⁸F]FPIA), for imaging the transcellular flux of short-chain fatty acids, and investigated whether this radiotracer can be used for the detection of glioma growth.

Methods

We evaluated the potential of [¹⁸F]FPIA PET to monitor tumor growth in orthotopic patient-derived (HSJD-GBM-001) and cell line-derived (U87, LN229) glioma xenografts, and also included [¹⁸F]FDG PET for comparison. We assessed proliferation (Ki-67) and the ex

SUBMITTER: Vassileva V 

PROVIDER: S-EPMC8301305 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature