Thermosensory Transient Receptor Potential Ion Channels and Asthma.

ABSTRACT: Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. The reception of physical and chemical environmental stimuli and the regulation of body temperature are mediated by thermosensory channels, members of a subfamily of transient receptor potential (TRP) ion channels. It has been found that genes encoding vanilloid, ankyrin, and melastatin TRP channels are involved in the development of some asthma phenotypes and in the formation of exacerbations of this pathology. The review summarizes modern views on the role of high and low temperatures in airway inflammation in asthma. The participation o

SUBMITTER: Kytikova OY 

PROVIDER: S-EPMC8301310 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature