Optimization and Development of Albumin-Biopolymer Bioconjugates with Solubility-Improving Properties.

ABSTRACT: Bioconjugation is an emerging field in the food and pharmaceutical industry. Due to its biocompatibility and high ligand binding capacity, albumin is widely used in modern drug delivery systems. However, the protein is sensitive to environmental stresses; albumin conjugates, on the other hand, have improved functional properties. Biopolymers are gaining interest due to their biodegradability and safety, compared to synthetic polymers. In this study, albumin-biopolymer bioconjugates were prepared by nonenzymatic Maillard reaction at 60 °C and 80% relative humidity. This nonenzymatic conjugation takes place between reducing sugars and available amino groups of a protein in certain conditions. The optimal molar ratio and time for the conjugation were studied by several investigation methods,

SUBMITTER: Papay ZE 

PROVIDER: S-EPMC8301381 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature