Dataset Information

Acute Myocardial Infarction Caused by Distal Embolization From a Proximal Ruptured Plaque.

ABSTRACT: Generally, in acute myocardial infarction, the plaque rupture site is around the occluded site. In this case, coronary angioscopy effectively detected a rupture at a nonstenotic lesion, and the consequent thrombotic occlusion may lead to acute myocardial infarction apart from rupture. Aspirated plaques contained atheromatous materials, cholesterol crystals, and fibrin. (Level of Difficulty: Intermediate.).

SUBMITTER: Komatsu S

PROVIDER: S-EPMC8301512 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Acute Myocardial Infarction Caused by Distal Embolization From a Proximal Ruptured Plaque.

Komatsu Sei S Yutani Chikao C Takahashi Satoru S Kodama Kazuhisa K

JACC. Case reports 20200115 1

Generally, in acute myocardial infarction, the plaque rupture site is around the occluded site. In this case, coronary angioscopy effectively detected a rupture at a nonstenotic lesion, and the consequent thrombotic occlusion may lead to acute myocardial infarction apart from rupture. Aspirated plaques contained atheromatous materials, cholesterol crystals, and fibrin. (<b>Level of Difficulty: Intermediate.</b>). ...[more]

PMID: 34316960

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Project description:BackgroundPreclinical data suggest that an acute inflammatory response following myocardial infarction (MI) accelerates systemic atherosclerosis. Using combined positron emission and computed tomography, we investigated whether this phenomenon occurs in humans.Methods and resultsOverall, 40 patients with MI and 40 with stable angina underwent thoracic 18F-fluorodeoxyglucose combined positron emission and computed tomography scan. Radiotracer uptake was measured in aortic atheroma and nonvascular tissue (paraspinal muscle). In 1003 patients enrolled in the Global Registry of Acute Coronary Events, we assessed whether infarct size predicted early (≤30 days) and late (>30 days) recurrent coronary events. Compared with patients with stable angina, patients with MI had higher aortic 18F-fluorodeoxyglucose uptake (tissue-to-background ratio 2.15±0.30 versus 1.84±0.18, P<0.0001) and plasma C-reactive protein concentrations (6.50 [2.00 to 12.75] versus 2.00 [0.50 to 4.00] mg/dL, P=0.0005) despite having similar aortic (P=0.12) and less coronary (P=0.006) atherosclerotic burden and similar paraspinal muscular 18F-fluorodeoxyglucose uptake (P=0.52). Patients with ST-segment elevation MI had larger infarcts (peak plasma troponin 32 300 [10 200 to >50 000] versus 3800 [1000 to 9200] ng/L, P<0.0001) and greater aortic 18F-fluorodeoxyglucose uptake (2.24±0.32 versus 2.02±0.21, P=0.03) than those with non-ST-segment elevation MI. Peak plasma troponin concentrations correlated with aortic 18F-fluorodeoxyglucose uptake (r=0.43, P=0.01) and, on multivariate analysis, independently predicted early (tertile 3 versus tertile 1: relative risk 4.40 [95% CI 1.90 to 10.19], P=0.001), but not late, recurrent MI.ConclusionsThe presence and extent of MI is associated with increased aortic atherosclerotic inflammation and early recurrent MI. This finding supports the hypothesis that acute MI exacerbates systemic atherosclerotic inflammation and remote plaque destabilization: MI begets MI.Clinical trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01749254.

Dataset Information

Acute Myocardial Infarction Caused by Distal Embolization From a Proximal Ruptured Plaque.

Publications

Acute Myocardial Infarction Caused by Distal Embolization From a Proximal Ruptured Plaque.

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