Metabolomics analysis of the serum from children with urolithiasis using UPLC-MS.

ABSTRACT: Pediatric urolithiasis is a common urologic disease with high morbidity and recurrence rates. Recent studies have shown that metabolic dysfunction plays a vital role in the pathogenesis of urolithiasis, especially in children, but the specific mechanism is still unclear. Metabolomics is an ideal technology for exploring the mechanism of metabolic disorders in urolithiasis. In the present study, a serum metabolomics based on ultra-performance liquid chromatography mass spectrometry was performed. A total of 50 children subjects were recruited for the study, including 30 patients with kidney stones and 20 normal controls (NCs). Principal component analysis and orthogonal partial least-squares determinant analysis were carried, and 40 metabolites were found to be significantly altered in pati

SUBMITTER: Wen J 

PROVIDER: S-EPMC8301561 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature