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A Middle-Aged Man Presenting With Progressive Heart Failure, Myopathy, and Monoclonal Gammopathy of Uncertain Significance.

ABSTRACT: A 48-year-old man presented with rapidly progressive heart failure and monoclonal gammopathy of uncertain significance. No specific cause was detected on endomyocardial biopsy. As the heart failure worsened, he also developed progressive skeletal myopathy. This provided the clue to the diagnosis, and cardiac function recovered rapidly with cause-directed therapy. (Level of Difficulty: Intermediate.).

SUBMITTER: Broch K

PROVIDER: S-EPMC8301701 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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A Middle-Aged Man Presenting With Progressive Heart Failure, Myopathy, and Monoclonal Gammopathy of Uncertain Significance.

Broch Kaspar K Popperud Trine T Gude Einar E Fløisand Yngvar Y Antal Ellen-Ann EA Bosse Gerhard G Jonsrud Christoffer C Hegard Terje T Skaara Silje S Elsais Ahmed A

JACC. Case reports 20200408 5

A 48-year-old man presented with rapidly progressive heart failure and monoclonal gammopathy of uncertain significance. No specific cause was detected on endomyocardial biopsy. As the heart failure worsened, he also developed progressive skeletal myopathy. This provided the clue to the diagnosis, and cardiac function recovered rapidly with cause-directed therapy. (<b>Level of Difficulty: Intermediate.</b>). ...[more]

PMID: 34317348

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