Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing.

ABSTRACT: Cutaneous wound healing is a vital biological process that aids skin regeneration upon injury. Wound healing failure results from persistent inflammatory conditions observed in diabetes, or autoimmune diseases like psoriasis. Chronic wounds are incurable due to factors like poor oxygenation, aberrant function of peripheral sensory nervature, inadequate nutrients and blood tissue supply. The most significant hallmark of chronic wounds is heavily aberrant immune skin function. The immune response in humans relies on a large network of signalling molecules and their interactions. Research studies have reported on the dual role of host defence peptides (HDPs), which are also often called antimicrobial peptides (AMPs). Their duality reflects their potential for acting as antibacterial peptides,

SUBMITTER: Petkovic M 

PROVIDER: S-EPMC8301823 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature