Wrestling and Wrapping: A Perspective on SUMO Proteins in Schwann Cells.

ABSTRACT: Schwann cell development and peripheral nerve myelination are finely orchestrated multistep processes; some of the underlying mechanisms are well described and others remain unknown. Many posttranslational modifications (PTMs) like phosphorylation and ubiquitination have been reported to play a role during the normal development of the peripheral nervous system (PNS) and in demyelinating neuropathies. However, a relatively novel PTM, SUMOylation, has not been studied in these contexts. SUMOylation involves the covalent attachment of one or more small ubiquitin-like modifier (SUMO) proteins to a substrate, which affects the function, cellular localization, and further PTMs of the conjugated protein. SUMOylation also regulates other proteins indirectly by facilitating non-covalent protein-pr

SUBMITTER: Fergani IF 

PROVIDER: S-EPMC8301837 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature