Acute MPTP Treatment Impairs Dendritic Spine Density in the Mouse Hippocampus.

ABSTRACT: Among the animal models of Parkinson's disease (PD), the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model has shown both dopaminergic (DA) damage and related motor control defects, as observed in patients with PD. Recent studies have suggested that the DA system interacts with the synaptic plasticity of the hippocampus in PD. However, little is known about how alterations in the hippocampal structural plasticity are affected by the DA damage in MPTP-lesioned models. In the present study, we investigated alterations in dendritic complexity and spine density in the mouse hippocampus following acute MPTP treatment (22 mg/kg, intraperitoneally, four times/day, 2-h intervals). We confirmed that acute MPTP treatment significantly decreased initial motor function and persi

SUBMITTER: Weerasinghe-Mudiyanselage PDE 

PROVIDER: S-EPMC8301854 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature