Can Glycosylation Mask the Detection of MHC Expressing p53 Peptides by T Cell Receptors?

ABSTRACT: Proteins of the major histocompatibility complex (MHC) class I, or human leukocyte antigen (HLA) in humans interact with endogenous peptides and present them to T cell receptors (TCR), which in turn tune the immune system to recognize and discriminate between self and foreign (non-self) peptides. Of especial importance are peptides derived from tumor-associated antigens. T cells recognizing these peptides are found in cancer patients, but not in cancer-free individuals. What stimulates this recognition, which is vital for the success of checkpoint based therapy? A peptide derived from the protein p53 (residues 161-169 or p161) was reported to show this behavior. T cells recognizing this unmodified peptide could be further stimulated in vitro to create effective cancer killing CTLs (cytotox

SUBMITTER: Nguyen TB 

PROVIDER: S-EPMC8301869 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature